| http://purl.uniprot.org/citations/19104471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19104471 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectiveInvestigation of a possible involvement of differences in human leukocyte antigens (HLA) in the risk of nevirapine (NVP)-induced skin rash among HIV-infected patients.MethodsA step-wise case-control association study was conducted. The first set of samples consisted of 80 samples from patients with NVP-induced skin rash and 80 samples from NVP-tolerant patients. These patients were genotyped for the HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQB1, and HLA-DPB1 by a sequence-based HLA typing method. Subsequently, we verified HLA alleles that showed a possible association in the first screening using an additional set of samples consisting of 67 cases with NVP-induced skin rash and 105 controls.ResultsAn HLA-B*3505 allele revealed a significant association with NVP-induced skin rash in the first and second screenings. In the combined data set, the HLA-B*3505 allele was observed in 17.5% of the patients with NVP-induced skin rash compared with only 1.1% observed in NVP-tolerant patients [odds ratio (OR)=18.96; 95% confidence interval (CI)=4.87-73.44, Pc=4.6x10] and 0.7% in general Thai population (OR=29.87; 95% CI=5.04-175.86, Pc=2.6x10). The logistic regression analysis also indicated HLA-B*3505 to be significantly associated with skin rash with OR of 49.15 (95% CI=6.45-374.41, P=0.00017).ConclusionA strong association between the HLA-B*3505 and NVP-induced skin rash provides a novel insight into the pathogenesis of drug-induced rash in the HIV-infected population. On account of its high specificity (98.9%) in identifying NVP-induced rash, it is possible to utilize the HLA-B*3505 as a marker to avoid a subset of NVP-induced rash, at least in Thai population."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.org/dc/terms/identifier | "doi:10.1097/fpc.0b013e32831d0faf"xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Mushiroda T."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Sura T."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Tantisiriwat W."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Chantratita W."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Kiertiburanakul S."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Sungkanuparph S."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Mahasirimongkol S."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Chantarangsu S."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Charoenyingwattana A."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/author | "Manosuthi W."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/name | "Pharmacogenet Genomics"xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/pages | "139-146"xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/title | "HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients."xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/19104471 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19104471 |
| http://purl.uniprot.org/citations/19104471 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19104471 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-19104471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19104471 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-19104471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19104471 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-19104471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19104471 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C545-mappedCitation-19104471 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19104471 |