| http://purl.uniprot.org/citations/19104664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19104664 | http://www.w3.org/2000/01/rdf-schema#comment | "OBF1, also known as Bob.1 or OCA-B, is a B lymphocyte-specific transcription factor which coactivates Oct1 and Oct2 on B cell specific promoters. So far, the function of OBF1 has been mainly identified in late stage B cell populations. The central defect of OBF1 deficient mice is a severely reduced immune response to T cell-dependent antigens and a lack of germinal center formation in the spleen. Relatively little is known about a potential function of OBF1 in developing B cells. Here we have generated transgenic mice overexpressing OBF1 in B cells under the control of the immunoglobulin heavy chain promoter and enhancer. Surprisingly, these mice have greatly reduced numbers of follicular B cells in the periphery and have a compromised immune response. Furthermore, B cell differentiation is impaired at an early stage in the bone marrow: a first block is observed during B cell commitment and a second differentiation block is seen at the large preB2 cell stage. The cells that succeed to escape the block and to differentiate into mature B cells have post-translationally downregulated the expression of transgene, indicating that expression of OBF1 beyond the normal level early in B cell development is deleterious. Transcriptome analysis identified genes deregulated in these mice and Id2 and Id3, two known negative regulators of B cell differentiation, were found to be upregulated in the EPLM and preB cells of the transgenic mice. Furthermore, the Id2 and Id3 promoters contain octamer-like sites, to which OBF1 can bind. These results provide evidence that tight regulation of OBF1 expression in early B cells is essential to allow efficient B lymphocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0004007"xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/author | "Kohler H."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/author | "Bordon A."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/author | "Rolink A.G."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/author | "Matthias P."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/author | "Bartholdy B."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/author | "Du Roure C."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/author | "Matthias G."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/author | "Bosco N."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/pages | "e4007"xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/title | "Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development."xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/19104664 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19104664 |
| http://purl.uniprot.org/citations/19104664 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19104664 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SRM5-mappedCitation-19104664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19104664 |
| http://purl.uniprot.org/uniprot/#_Q64693-mappedCitation-19104664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19104664 |
| http://purl.uniprot.org/uniprot/#_Q6PDN2-mappedCitation-19104664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19104664 |
| http://purl.uniprot.org/uniprot/#_Q542H4-mappedCitation-19104664 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19104664 |
| http://purl.uniprot.org/uniprot/Q542H4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19104664 |
| http://purl.uniprot.org/uniprot/Q64693 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19104664 |
| http://purl.uniprot.org/uniprot/Q6PDN2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19104664 |