| http://purl.uniprot.org/citations/19109136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19109136 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19109136 | http://www.w3.org/2000/01/rdf-schema#comment | "CD160 has been initially identified as a GPI-anchored MHC-class I activating receptor mainly expressed on peripheral blood NK cells. Herein, we report the identification of three additional CD160-related mRNAs generated through alternative splicings of the CD160 gene, among which one encoded a putative CD160 transmembrane isoform (CD160-TM). We first establish that CD160-TM surface expression is highly restricted to NK cells and is activation-dependent. Additionally, we provide evidence that CD160-TM represents a novel activating receptor, as assessed by the increased CD107a NK cell surface mobilization observed upon its engagement. Finally, we demonstrate that the CD160-TM cytoplasmic tail is by itself sufficient to mediate the recruitment of Erk1/2 signaling pathway, and that the initiation of this activation process is dependent on the Src-family kinase p56(lck). The identification of CD160-TM therefore provides new possibilities regarding the role of CD160 isoforms in the regulation of NK cell functions."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.182.1.63"xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.182.1.63"xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/author | "Bensussan A."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/author | "Bensussan A."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/author | "Giustiniani J."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/author | "Giustiniani J."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/author | "Marie-Cardine A."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/author | "Marie-Cardine A."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/pages | "63-71"xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/pages | "63-71"xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/title | "Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/title | "Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation."xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19109136 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19109136 |
| http://purl.uniprot.org/citations/19109136 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19109136 |
| http://purl.uniprot.org/citations/19109136 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19109136 |
| http://purl.uniprot.org/citations/19109136 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19109136 |