| http://purl.uniprot.org/citations/19109239 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19109239 | http://www.w3.org/2000/01/rdf-schema#comment | "Although interleukin-4 (IL-4) and IL-13 participate in allergic inflammation and share a receptor subunit (IL-4Ralpha), they have different functions. We compared cells expressing type I and II IL-4Rs with cells expressing only type II receptors for their responsiveness to these cytokines. IL-4 induced highly efficient, gammaC-dependent tyrosine phosphorylation of insulin receptor substrate 2 (IRS-2), whereas IL-13 was less effective, even when phosphorylation of signal transducer and activator of transcription 6 (STAT6) was maximal. Only type I receptor, gammaC-dependent signaling induced efficient association of IRS-2 with the p85 subunit of phosphoinositide 3-kinase or the adaptor protein growth factor receptor-bound protein 2. In addition, IL-4 signaling through type I IL-4Rs induced more robust expression of a subset of genes associated with alternatively activated macrophages than did IL-13. Thus, IL-4 activates signaling pathways through type I IL-4Rs qualitatively differently from IL-13, which cooperate to induce optimal gene expression."xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.1164795"xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/author | "Qi X."xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/author | "Vogel S.N."xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/author | "Paul W.E."xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/author | "Heller N.M."xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/author | "Keegan A.D."xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/author | "Shirey K.A."xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/author | "Junttila I.S."xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/pages | "ra17"xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/title | "Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages."xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/19109239 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19109239 |
| http://purl.uniprot.org/citations/19109239 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19109239 |
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