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http://purl.uniprot.org/citations/19109693http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19109693http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

To describe the concentrations of sTREM-1 in patients with sepsis and to explore the effects of their serum on the expression of TREM-1 on U937 monocytes.

Methods

Blood was sampled at regular time intervals in 56 patients with sepsis. Concentrations of tumour necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1alpha), IL-6, IL-8, IL-10 and IL-12p70 and sTREM-1 were measured. U937 monocytes were incubated in the presence of serum at sepsis onset.

Results

Median sTREM-1 concentration on day 1 for patients with septic shock was 915 pg/ml and 228.5 pg/ml for those without shock (p = 0.002). TNFalpha, IL-1alpha, IL-6, IL-8 and IL-10 did not differ between them. A positive correlation was found between changes of sTREM-1 and SOFA scores from day 1 to 7. Sera of patients with septic shock evoked a significant increase of the expression of TREM-1. The concentrations of TNFalpha and IL-8 in supernatants increased only after stimulating with sera of patients without shock, but not after stimulating with sera of patients with shock.

Conclusions

Levels of sTREM-1 correlated with sepsis severity. sTREM-1 is considerably higher in patients with shock compared to patients without shock. The serum of shocked patients could stimulate the expression of TREM-1 on U937 monocytes."xsd:string
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http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Douka E."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Zervou M."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Giamarellos-Bourboulis E.J."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Kotanidou A."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Armaganidis A."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Augustatou C."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Dimopoulou I."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Orfanos S.E."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Pelekanou A."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Douzinas E."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Karagianni V."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Livaditi O."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/author"Theodorakopoulou M."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/name"Inflamm Res"xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/pages"127-132"xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/title"Serum of patients with septic shock stimulates the expression of Trem-1 on U937 monocytes."xsd:string
http://purl.uniprot.org/citations/19109693http://purl.uniprot.org/core/volume"58"xsd:string
http://purl.uniprot.org/citations/19109693http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19109693
http://purl.uniprot.org/citations/19109693http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19109693
http://purl.uniprot.org/uniprot/#_A8K7Z7-mappedCitation-19109693http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19109693
http://purl.uniprot.org/uniprot/#_Q38L15-mappedCitation-19109693http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19109693
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