| http://purl.uniprot.org/citations/19109891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19109891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19109891 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-dystroglycan (DG) and the dystrophin-glycoprotein complex (DGC) are localized at costameres and neuromuscular junctions in the sarcolemma of skeletal muscle. We present evidence for an ankyrin-based mechanism for sarcolemmal localization of dystrophin and beta-DG. Dystrophin binds ankyrin-B and ankyrin-G, while beta-DG binds ankyrin-G. Dystrophin and beta-DG require ankyrin-G for retention at costameres but not delivery to the sarcolemma. Dystrophin and beta-DG remain intracellular in ankyrin-B-depleted muscle, where beta-DG accumulates in a juxta-TGN compartment. The neuromuscular junction requires ankyrin-B for localization of dystrophin/utrophin and beta-DG and for maintenance of its postnatal morphology. A Becker muscular dystrophy mutation reduces ankyrin binding and impairs sarcolemmal localization of dystrophin-Dp71. Ankyrin-B also binds to dynactin-4, a dynactin subunit. Dynactin-4 and a subset of microtubules disappear from sarcolemmal sites in ankyrin-B-depleted muscle. Ankyrin-B thus is an adaptor required for sarcolemmal localization of dystrophin, as well as dynactin-4."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.10.018"xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.10.018"xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/author | "Bennett V."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/author | "Bennett V."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/author | "Ayalon G."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/author | "Ayalon G."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/author | "Davis J.Q."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/author | "Davis J.Q."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/author | "Scotland P.B."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/author | "Scotland P.B."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/pages | "1189-1200"xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/pages | "1189-1200"xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/title | "An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/title | "An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan."xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://purl.uniprot.org/core/volume | "135"xsd:string |
| http://purl.uniprot.org/citations/19109891 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19109891 |
| http://purl.uniprot.org/citations/19109891 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19109891 |