| http://purl.uniprot.org/citations/19111522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19111522 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19111522 | http://www.w3.org/2000/01/rdf-schema#comment | "The Tim23 protein is the key component of the mitochondrial import machinery. It locates to the inner mitochondrial membrane and its own import is dependent on the DDP1/TIM13 complex. Mutations in human DDP1 cause the Mohr-Tranebjaerg syndrome (MTS/DFN-1; OMIM #304700), which is one of the two known human diseases of the mitochondrial protein import machinery. We created a Tim23 knockout mouse from a gene trap embryonic stem cell clone. Homozygous Tim23 mice were not viable. Heterozygous F1 mutants showed a 50% reduction of Tim23 protein in Western blot, a neurological phenotype and a markedly reduced life span. Haploinsufficiency of the Tim23 mutation underlines the critical role of the mitochondrial import machinery for maintaining mitochondrial function."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbabio.2008.12.001"xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbabio.2008.12.001"xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Fuchs H."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Fuchs H."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Meitinger T."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Meitinger T."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "de Angelis M.H."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "de Angelis M.H."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Ahting U."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Ahting U."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Iuso A."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Iuso A."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Klopstock T."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Klopstock T."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Prokisch H."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Prokisch H."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Wurst W."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Wurst W."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Bender A."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Bender A."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Becker L."xsd:string |
| http://purl.uniprot.org/citations/19111522 | http://purl.uniprot.org/core/author | "Becker L."xsd:string |