| http://purl.uniprot.org/citations/19111657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19111657 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19111657 | http://www.w3.org/2000/01/rdf-schema#comment | "A key step in the Fanconi anemia (FA) tumor suppressor pathway is the site-specific monoubiquitination of the FANCD2 protein. Genetic studies indicate that this crucial modification requires eight known FA gene products and the E2-conjugating enzyme Ube2t. Here, we minimally reconstitute this monoubiquitination reaction with Ube2t and the FANCL protein, revealing that monoubiquitination is stimulated by a conserved RWD-like domain in FANCL. Furthermore, addition of the FANCI protein enhances monoubiquitination and also restricts it to the in vivo substrate lysine residue on FANCD2. This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2008.12.003"xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2008.12.003"xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/author | "Babu M.M."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/author | "Babu M.M."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/author | "Alpi A.F."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/author | "Alpi A.F."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/author | "Patel K.J."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/author | "Patel K.J."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/author | "Pace P.E."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/author | "Pace P.E."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/pages | "767-777"xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/pages | "767-777"xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/title | "Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/title | "Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI."xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/19111657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19111657 |
| http://purl.uniprot.org/citations/19111657 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19111657 |