| http://purl.uniprot.org/citations/19111665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19111665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19111665 | http://www.w3.org/2000/01/rdf-schema#comment | "The Dbf4/Drf1-dependent S-phase-promoting kinase Cdc7 (Ddk) is thought to be an essential target inactivated by the S-phase checkpoint machinery that inhibits DNA replication. However, we show here that the complex formation, chromatin association, and kinase activity of Ddk are not inhibited during the DNA-damage-induced S-phase checkpoint response in Xenopus egg extracts and mammalian cells. Instead, we find that Ddk plays an active role in regulating S-phase checkpoint signaling. Addition of purified Ddk to Xenopus egg extracts or overexpression of Dbf4 in HeLa cells downregulates ATR-Chk1 checkpoint signaling and overrides the inhibition of DNA replication and cell-cycle progression induced by DNA-damaging agents. These results indicate that Ddk functions as an upstream regulator to monitor S-phase checkpoint signaling. We propose that Ddk modulates the S-phase checkpoint control by attenuating checkpoint signaling and triggering DNA replication reinitiation during the S-phase checkpoint recovery."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2008.12.005"xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/author | "Jiang W."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/author | "Jiang W."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/author | "Lau E."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/author | "Lau E."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/author | "Tsuji T."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/author | "Tsuji T."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/author | "Chiang G.G."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/author | "Chiang G.G."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/pages | "862-869"xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/pages | "862-869"xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/title | "The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/title | "The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control."xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/19111665 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19111665 |
| http://purl.uniprot.org/citations/19111665 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19111665 |
| http://purl.uniprot.org/citations/19111665 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19111665 |