| http://purl.uniprot.org/citations/19111878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19111878 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor- or cancer-associated fibroblasts (TAFs or CAFs) from different tumors exhibit distinct angiogenic and tumorigenic properties. Unlike normal skin fibroblasts or TAFs from TIB6 tumors that are sensitive to anti-VEGF treatment (TAF-TIB6), TAFs from resistant EL4 tumors (TAF-EL4) can stimulate TIB6 tumor growth even when VEGF is inhibited. We show that platelet-derived growth factor C (PDGF-C) is upregulated in TAFs from resistant tumors. PDGF-C-neutralizing antibodies blocked the angiogenesis induced by such TAFs in vivo, slowed the growth of EL4 and admixture (TAF-EL4 + TIB6) tumors, and exhibited additive effects with anti-VEGF-A antibodies. Hence, our data reveal an additional mechanism for TAF-mediated tumorigenesis and suggest that some tumors may overcome inhibition of VEGF-mediated angiogenesis through upregulation of PDGF-C."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2008.12.004"xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/author | "Zhong C."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/author | "Wu X."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/author | "Yu L."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/author | "Modrusan Z."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/author | "Ferrara N."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/author | "Kasman I."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/author | "Kaminker J."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/author | "Crawford Y."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/name | "Cancer Cell"xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/pages | "21-34"xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/title | "PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment."xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/19111878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19111878 |
| http://purl.uniprot.org/citations/19111878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19111878 |
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| http://purl.uniprot.org/uniprot/#_B4E3A5-mappedCitation-19111878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19111878 |
| http://purl.uniprot.org/uniprot/#_Q8CI19-mappedCitation-19111878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19111878 |
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| http://purl.uniprot.org/uniprot/B4E3A5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19111878 |
| http://purl.uniprot.org/uniprot/Q9NRA1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19111878 |
| http://purl.uniprot.org/uniprot/B2R9K6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19111878 |