| http://purl.uniprot.org/citations/19112093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19112093 | http://www.w3.org/2000/01/rdf-schema#comment | "Class-A scavenger receptors (SR-A) and TLR mediate early immune responses against pathogenic bacteria. SR-A and TLR molecules are expressed on phagocytes and interact with common ligands from Gram-negative and Gram-positive bacteria; however, the contribution of TLR activity to SR-A-mediated phagocytosis has not been assessed directly. Herein, we provide genetic and functional evidence that ligand- and TLR-specific stimuli synergize with SR-A to mediate bacterial phagocytosis. Although complete loss of SR-A (SR-A(-/-)) is known to impair bacterial clearance, here we identify the first deficiency attributable to SR-A heterozygosity: SR-A(+/-)TLR4(+/-) cells and mice are impaired significantly in the clearance of Gram-negative Escherichia coli. This phenotype is specific to the TLR signaling event, as SR-A(+/-)TLR4(+/-) cells are not deficient for the clearance of Gram-positive Staphylococcus aureus bacteria, which contain cell-surface TLR2 ligands but lack TLR4 ligands. We demonstrate that this is a global, phagocytic mechanism, regulated independently by multiple TLRs, as analogous to the SR-A(+/-)TLR4(+/-) deficit, SR-A(+/-)TLR2(+/-) cells are impaired for S. aureus uptake. In support of this, we show that SR-A(+/-)MyD88(+/-) cells recapitulate the phagocytosis defect observed in SR-A(+/-)TLR4(+/-) cells. These data identify for the first time that TLR-driven innate immune responses, via a MyD88 signaling mechanism, regulate SR-A-dependent phagocytosis of bacteria. These findings provide novel insights into how innate immune cells control SR-A-mediated trafficking and are the first demonstration that subtle changes in the expression of SR-A and TLRs can substantially affect host bacterial clearance."xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.1008631"xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/author | "Alonso A."xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/author | "Berwin B."xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/author | "Uematsu S."xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/author | "Poynter M.E."xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/author | "Amiel E."xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/pages | "595-605"xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/title | "Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis."xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/19112093 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19112093 |
| http://purl.uniprot.org/citations/19112093 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19112093 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-19112093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19112093 |
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| http://purl.uniprot.org/uniprot/#_A2BHU8-mappedCitation-19112093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19112093 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-19112093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19112093 |
| http://purl.uniprot.org/uniprot/#_F6SPW1-mappedCitation-19112093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19112093 |
| http://purl.uniprot.org/uniprot/#_G3X8Y8-mappedCitation-19112093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19112093 |
| http://purl.uniprot.org/uniprot/#_L0CL36-mappedCitation-19112093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19112093 |