| http://purl.uniprot.org/citations/19112495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19112495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19112495 | http://www.w3.org/2000/01/rdf-schema#comment | "The Gram-positive bacterium Staphylococcus aureus, similar to other pathogens, binds human complement regulators Factor H and Factor H related protein 1 (FHR-1) from human serum. Here we identify the secreted protein Sbi (Staphylococcus aureus binder of IgG) as a ligand that interacts with Factor H by a-to our knowledge-new type of interaction. Factor H binds to Sbi in combination with C3b or C3d, and forms tripartite SbiratioC3ratioFactor H complexes. Apparently, the type of C3 influences the stability of the complex; surface plasmon resonance studies revealed a higher stability of C3d complexed to Sbi, as compared to C3b or C3. As part of this tripartite complex, Factor H is functionally active and displays complement regulatory activity. Sbi, by recruiting Factor H and C3b, acts as a potent complement inhibitor, and inhibits alternative pathway-mediated lyses of rabbit erythrocytes by human serum and sera of other species. Thus, Sbi is a multifunctional bacterial protein, which binds host complement components Factor H and C3 as well as IgG and beta(2)-glycoprotein I and interferes with innate immune recognition."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1000250"xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1000250"xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Richter J."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Richter J."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Skerka C."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Skerka C."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Zipfel P.F."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Zipfel P.F."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Reuter M."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Reuter M."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Burman J."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Burman J."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Haelbich S."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Haelbich S."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Haupt K."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "Haupt K."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "van den Elsen J."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/author | "van den Elsen J."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/name | "PLoS Pathog."xsd:string |
| http://purl.uniprot.org/citations/19112495 | http://purl.uniprot.org/core/name | "PLoS Pathog."xsd:string |