| http://purl.uniprot.org/citations/19114594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19114594 | http://www.w3.org/2000/01/rdf-schema#comment | "Two distinct pathways have recently been proposed for the import of peroxisomal membrane proteins (PMPs): a Pex19p- and Pex3p-dependent class I pathway and a Pex19p- and Pex3p-independent class II pathway. We show here that Pex19p plays an essential role as the chaperone for full-length Pex3p in the cytosol. Pex19p forms a soluble complex with newly synthesized Pex3p in the cytosol and directly translocates it to peroxisomes. Knockdown of Pex19p inhibits peroxisomal targeting of newly synthesized full-length Pex3p and results in failure of the peroxisomal localization of Pex3p. Moreover, we demonstrate that Pex16p functions as the Pex3p-docking site and serves as the peroxisomal membrane receptor that is specific to the Pex3p-Pex19p complexes. Based on these novel findings, we suggest a model for the import of PMPs that provides new insights into the molecular mechanisms underlying the biogenesis of peroxisomes and its regulation involving Pex3p, Pex19p, and Pex16p."xsd:string |
| http://purl.uniprot.org/citations/19114594 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200806062"xsd:string |
| http://purl.uniprot.org/citations/19114594 | http://purl.uniprot.org/core/author | "Fujiki Y."xsd:string |
| http://purl.uniprot.org/citations/19114594 | http://purl.uniprot.org/core/author | "Matsuzaki T."xsd:string |
| http://purl.uniprot.org/citations/19114594 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19114594 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19114594 | http://purl.uniprot.org/core/pages | "1275-1286"xsd:string |
| http://purl.uniprot.org/citations/19114594 | http://purl.uniprot.org/core/title | "The peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p- and Pex16p-dependent pathway."xsd:string |
| http://purl.uniprot.org/citations/19114594 | http://purl.uniprot.org/core/volume | "183"xsd:string |
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