| http://purl.uniprot.org/citations/19115207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19115207 | http://www.w3.org/2000/01/rdf-schema#comment | "Superficial pT1 bladder tumors are characterized by a high risk of recurrence and progression in grade and stage. Few studies provided evidence that loss of adipocyte-fatty acid binding protein (A-FABP) expression was associated with bladder cancer progression. A-FABP is a lipid binding protein playing a role in intracellular lipid transport and metabolism, as well as in signal transduction. We reported from bladder tumors that decrease of A-FABP transcript level significantly correlated to tumor stage and to histologic grade (p < 0.05). Namely, in poor prognosis high grade pT1 tumors there was a loss of A-FABP expression compared to good prognosis tumors suggesting that re-expression of A-FABP could be a therapeutic approach in early stage bladder cancer to prevent disease progression. We demonstrated for the first time that this marker is upregulated by Peroxisome Proliferator-Activated Receptor (PPAR) alpha, beta and gamma in T24 cells (derived from an undifferentiated grade III carcinoma) and only by PPARbeta in RT4 cells (derived from a well differentiated grade I papillary tumor). This effect occurred through a PPAR-dependent transcriptional mechanism without modifying mRNA stability and interestingly required de novo protein synthesis. Data as a whole suggest a prognostic significance of A-FABP in bladder cancer outcome and the potential utility of overexpression of this protein by PPAR agonists open up new perspectives in the treatment of bladder cancer. (c) 2008 Wiley-Liss, Inc."xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.24112"xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/author | "Roche E."xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/author | "Bittard H."xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/author | "Fauconnet S."xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/author | "Lascombe I."xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/author | "Clairotte A."xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/author | "Plissonnier M.L."xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/author | "Boiteux G."xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/pages | "1820-1828"xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/title | "A-FABP, a candidate progression marker of human transitional cell carcinoma of the bladder, is differentially regulated by PPAR in urothelial cancer cells."xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/19115207 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19115207 |
| http://purl.uniprot.org/citations/19115207 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19115207 |
| http://purl.uniprot.org/uniprot/#_Q15528-mappedCitation-19115207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19115207 |
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| http://purl.uniprot.org/uniprot/#_P37231-mappedCitation-19115207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19115207 |
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| http://purl.uniprot.org/uniprot/#_O95402-mappedCitation-19115207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19115207 |