| http://purl.uniprot.org/citations/19115252 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19115252 | http://www.w3.org/2000/01/rdf-schema#comment | "Hox genes contain a homeobox encoding a 60-amino acid DNA binding sequence. The Hoxa1 gene (Hox1.6, ERA1) encodes two alternatively spliced mRNAs that encode distinct proteins, one with the homeodomain (Hoxa1-993), and another protein lacking this domain (Hoxa1-399). The functions of Hoxa1-399 are unknown. We detected Hoxa1-993 and Hoxa1-399 by immunoprecipitation using Hoxa1 antibodies. To assess whether Hoxa1-399 functions in cellular differentiation, we analyzed Hoxb1, a Hoxa1 target gene. Hoxa1-993 and its cofactor, Pbx1, bind to the Hoxb1 SOct-R3 promoter to transcriptionally activate a luciferase reporter. Results from F9 stem cells that stably express ectopic Hoxa1-399 (the F9-399 line) show that Hoxa1-399 reduces this transcriptional activation. Gel shift assays demonstrate that Hoxa1-399 reduces Hoxa1-993/Pbx1 binding to the Hoxb1 SOct-R3 region. GST pull-down experiments suggest that Hoxa1-399, Hoxa1-993, and Pbx1 form a trimer. However, the F9-399 line exhibits no differences in RA-induced proliferation arrest or endogenous Hoxb1, Pbx1, Hoxa5, Cyp26a1, GATA4, or Meis mRNA levels when compared to F9 wild-type."xsd:string |
| http://purl.uniprot.org/citations/19115252 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.22023"xsd:string |
| http://purl.uniprot.org/citations/19115252 | http://purl.uniprot.org/core/author | "Gudas L.J."xsd:string |
| http://purl.uniprot.org/citations/19115252 | http://purl.uniprot.org/core/author | "Fernandez C.C."xsd:string |
| http://purl.uniprot.org/citations/19115252 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19115252 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/19115252 | http://purl.uniprot.org/core/pages | "427-443"xsd:string |
| http://purl.uniprot.org/citations/19115252 | http://purl.uniprot.org/core/title | "The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells."xsd:string |
| http://purl.uniprot.org/citations/19115252 | http://purl.uniprot.org/core/volume | "106"xsd:string |
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