| http://purl.uniprot.org/citations/19119233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19119233 | http://www.w3.org/2000/01/rdf-schema#comment | "Chaperone-mediated autophagy controls the degradation of selective cytosolic proteins and may protect neurons against degeneration. In a neuronal cell line, we found that chaperone-mediated autophagy regulated the activity of myocyte enhancer factor 2D (MEF2D), a transcription factor required for neuronal survival. MEF2D was observed to continuously shuttle to the cytoplasm, interact with the chaperone Hsc70, and undergo degradation. Inhibition of chaperone-mediated autophagy caused accumulation of inactive MEF2D in the cytoplasm. MEF2D levels were increased in the brains of alpha-synuclein transgenic mice and patients with Parkinson's disease. Wild-type alpha-synuclein and a Parkinson's disease-associated mutant disrupted the MEF2D-Hsc70 binding and led to neuronal death. Thus, chaperone-mediated autophagy modulates the neuronal survival machinery, and dysregulation of this pathway is associated with Parkinson's disease."xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1166088"xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/author | "Lee M."xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/author | "Mao Z."xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/author | "Gearing M."xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/author | "She H."xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/author | "Colla E."xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/author | "Shacka J.J."xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/pages | "124-127"xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/title | "Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy."xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://purl.uniprot.org/core/volume | "323"xsd:string |
| http://purl.uniprot.org/citations/19119233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19119233 |
| http://purl.uniprot.org/citations/19119233 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19119233 |
| http://purl.uniprot.org/uniprot/#_D3Z5E2-mappedCitation-19119233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19119233 |
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| http://purl.uniprot.org/uniprot/#_Q3UXU1-mappedCitation-19119233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19119233 |