| http://purl.uniprot.org/citations/19120309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19120309 | http://www.w3.org/2000/01/rdf-schema#comment | "This study aimed to investigate whether carboxypeptidase-H antibody (CPH-Ab) can help identify latent autoimmune diabetes in adults (LADA). Phenotypic type 2 diabetic (T2D) patients (n= 1296) were studied for CPH Abs and autoantibodies to glutamic acid decarboxylase (GAD-Abs). CPH-Ab(+) T2D patients also underwent testing for insulinoma protein tyrosine phosphatase (IA-2A). Clinical features were compared among CPH-Ab(+), GAD-Ab(+), and Ab(-) T2D patients. Some of the antibody-positive patients were followed up for 3 years to assess beta cell function. The prevalence of CPH-Abs in T2D patients was 4.8%, significantly higher than that in controls. Double positivity was rare between CPH-Abs and GAD-Abs or IA-2A. Compared to patients with Ab(-) T2D, those with CPH-Ab(+) T2D had lower BMI, lower fasting C-peptide (FCP) levels, and more frequent ketosis, while not as much as did those with GAD-Ab(+) T2D. The mild beta cell dysfunction in patients with CPH-Ab(+) T2D was associated with their longer duration of diabetes. No marked change of C-peptide in the CPH-Ab(+) group was found during follow-up. These findings demonstrated that CPH-Abs may allow discrimination of a more latent subset of adult-onset autoimmune diabetes (LADA) whose features are intermediate between those with classic GAD-Ab(+) LADA and patients with Ab(-) T2D."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.org/dc/terms/identifier | "doi:10.1196/annals.1447.037"xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/author | "Huang G."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/author | "Jin P."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/author | "Peng H."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/author | "Zhou Z.G."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/author | "Hagopian W."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/author | "Tan S.Z."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/name | "Ann N Y Acad Sci"xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/pages | "263-266"xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/title | "Carboxypeptidase-H autoantibodies differentiate a more latent subset of autoimmune diabetes from phenotypic type 2 diabetes among Chinese adults."xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://purl.uniprot.org/core/volume | "1150"xsd:string |
| http://purl.uniprot.org/citations/19120309 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19120309 |
| http://purl.uniprot.org/citations/19120309 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19120309 |
| http://purl.uniprot.org/uniprot/#_A0A384N679-mappedCitation-19120309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19120309 |
| http://purl.uniprot.org/uniprot/#_A0A7S9TQK2-mappedCitation-19120309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19120309 |
| http://purl.uniprot.org/uniprot/#_B3KXD3-mappedCitation-19120309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19120309 |
| http://purl.uniprot.org/uniprot/#_P16870-mappedCitation-19120309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19120309 |
| http://purl.uniprot.org/uniprot/A0A384N679 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19120309 |
| http://purl.uniprot.org/uniprot/P16870 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19120309 |