| http://purl.uniprot.org/citations/19122139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19122139 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene knockout experiments in mice have suggested a hierarchical model of early B cell commitment wherein E2A proteins (E47 and E12) activate early B cell factor (Ebf1), which in turn activates expression of the B cell commitment factor, Pax5. In IL-7 receptor alpha (IL-7Ralpha) knockout mice, B cell development is blocked before B-lineage commitment at the prepro-B cell stage in adult animals. In IL-7Ralpha(-/-) prepro-B cells, E47 is expressed and yet is insufficient to transcriptionally activate the putative downstream target gene, Ebf1. In this study, we show that further increases of E47 expression in IL-7Ralpha(-/-) prepro-B cells fails to activate Ebf1, but rather leads to a dramatic induction of the E2A inhibitory factors, Id2 and Id3. In contrast, enforced expression of Ebf1 in IL-7Ralpha(-/-) bone marrow potently down-regulates Id2 and Id3 mRNA expression and restores B cell differentiation in vivo. Down-regulation of both Id2 and Id3 during B cell specification is essential in that overexpression of either Id2 or Id3 in wild-type bone marrow blocks B cell specification at the prepro-B cell stage. Collectively, these studies suggest a model where Ebf1 induction specifies the B cell fate by dramatically increasing activity of E47 at the posttranslational level."xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0802550106"xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/author | "Gao H."xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/author | "Kim H.G."xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/author | "He T."xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/author | "Hagman J."xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/author | "Klug C.A."xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/author | "Carvalho T.L."xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/author | "Thal M.A."xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/pages | "552-557"xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/title | "Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage."xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19122139 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19122139 |
| http://purl.uniprot.org/citations/19122139 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19122139 |
| http://purl.uniprot.org/uniprot/#_Q07802-mappedCitation-19122139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19122139 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J011-mappedCitation-19122139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19122139 |
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| http://purl.uniprot.org/uniprot/#_A0A2I3BRC2-mappedCitation-19122139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19122139 |
| http://purl.uniprot.org/uniprot/#_D3Z037-mappedCitation-19122139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19122139 |
| http://purl.uniprot.org/uniprot/#_E9PWE2-mappedCitation-19122139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19122139 |
| http://purl.uniprot.org/uniprot/#_E9PWE3-mappedCitation-19122139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19122139 |