| http://purl.uniprot.org/citations/19123132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19123132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19123132 | http://www.w3.org/2000/01/rdf-schema#comment | "In Drosophila melanogaster, transformer-2 (TRA-2) which is a non-sex-specific auxiliary splicing factor, is required to promote female sexual differentiation by interaction with the female-specific TRA. The two proteins positively regulate the splicing of both doublesex (dsx) and fruitless (fru) pre-mRNAs, which in turn regulate phenotypic and behavioural sexual dimorphism. In the Mediterranean fruitfly Ceratitis capitata, the female-specific CcTRA is similarly required not only for Ccdsx splicing, but also to exert a novel autoregulatory function that consists of promoting female-specific splicing of Cctra pre-mRNA. This study reports the isolation and functional analysis of the C. capitata homologue of the Drosophila transformer-2 gene (Cctra-2). Transient RNAi against Cctra-2 during embryonic development causes the full sex reversal of XX flies in adult fertile pseudo-males, as well as changes in the splicing pattern of Cctra, Ccdsx and Ccfruitless (Ccfru). We propose that: 1) Cctra-2, as in Drosophila, is necessary for promoting Ccdsx and putative Ccfru pre-mRNA female-specific splicing and that 2) unlike in Drosophila, Cctra-2 appears to be necessary for establishing female sex determination in early XX embryos and for maintaining the positive feedback regulation of Cctra during development."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.org/dc/terms/identifier | "doi:10.1387/ijdb.082681ms"xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.org/dc/terms/identifier | "doi:10.1387/ijdb.082681ms"xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Atkinson P."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Atkinson P."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Robertson M."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Robertson M."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Polito L.C."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Polito L.C."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Saccone G."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Saccone G."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Salvemini M."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Salvemini M."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Aronson B."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/author | "Aronson B."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/name | "Int. J. Dev. Biol."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/name | "Int J Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/pages | "109-120"xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/pages | "109-120"xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/title | "Ceratitis capitata transformer-2 gene is required to establish and maintain the autoregulation of Cctra, the master gene for female sex determination."xsd:string |
| http://purl.uniprot.org/citations/19123132 | http://purl.uniprot.org/core/title | "Ceratitis capitata transformer-2 gene is required to establish and maintain the autoregulation of Cctra, the master gene for female sex determination."xsd:string |