| http://purl.uniprot.org/citations/19124519 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19124519 | http://www.w3.org/2000/01/rdf-schema#comment | "Benign breast disease (BBD) is a risk factor for breast cancer and may have a heritable component. Deficient DNA repair has been implicated in breast cancer etiology and may exert its effect before BBD, a known precursor. The association between allelic variants in DNA repair genes and BBD was examined in a cohort of women in Washington County, Maryland. BBD was defined by two criteria: (a) a physician diagnosis of BBD or fibrocystic disease and/or (b) a benign breast biopsy. 3,212 women without BBD at baseline were genotyped for 12 candidate single nucleotide polymorphisms in seven DNA repair genes. Of these women, 482 subsequently reported a diagnosis of BBD. The Cox model was used to calculate hazard ratios (HR). Variant alleles of XRCC1 Arg(194)Trp (rs1799782) and ERCC4 Arg(415)Gln (rs1800067) were significantly associated with BBD [HR, 1.36; 95% confidence interval (95% CI), 1.06-1.74 and HR, 1.39; 95% CI, 1.09-1.76, respectively]. Similar estimates were also observed for each of the BBD criterion used. The BBD association for ERCC4 was even stronger among women with a family history of breast cancer (HR, 2.68; 95% CI, 1.52-4.66; P(interaction) = 0.02). This study suggests that variant alleles in DNA repair genes may modify BBD risk, a potential intermediate marker of breast cancer risk, particularly among high-risk subgroups."xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.org/dc/terms/identifier | "doi:10.1158/1055-9965.epi-08-0659"xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/author | "Jorgensen T.J."xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/author | "Helzlsouer K.J."xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/author | "Visvanathan K."xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/author | "Crum R.M."xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/author | "Bolton J.H."xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/author | "Clipp S.C."xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/name | "Cancer Epidemiol Biomarkers Prev"xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/pages | "346-350"xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/title | "DNA repair gene variants associated with benign breast disease in high cancer risk women."xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/19124519 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19124519 |
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