| http://purl.uniprot.org/citations/19124611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19124611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19124611 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently characterized human hnRNP L as a global regulator of alternative splicing, binding to CA-repeat and CA-rich elements. Here we report that hnRNP L autoregulates its own expression on the level of alternative splicing. Intron 6 of the human hnRNP L gene contains a short exon that, if used, introduces a premature termination codon, resulting in nonsense-mediated decay (NMD). This "poison exon" is preceded by a highly conserved CA-rich cluster extending over 800 nucleotides that binds hnRNP L and functions as an unusually extended, intronic enhancer, promoting inclusion of the poison exon. As a result, excess hnRNP L activates NMD of its own mRNA, thereby creating a negative autoregulatory feedback loop and contributing to homeostasis of hnRNP L levels. We present experimental evidence for this mechanism, based on NMD inactivation, hnRNP L binding assays, and hnRNP L-dependent alternative splicing of heterologous constructs. In addition, we demonstrate that hnRNP L cross-regulates inclusion of an analogous poison exon in the hnRNP L-like pre-mRNA, which explains the reciprocal expression of the two closely related hnRNP L proteins."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01689-08"xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01689-08"xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Schreiner S."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Schreiner S."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Hung L.H."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Hung L.H."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Hui J."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Hui J."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Grishina I."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Grishina I."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Bindereif A."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Bindereif A."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Heiner M."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Heiner M."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Rossbach O."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/author | "Rossbach O."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/pages | "1442-1451"xsd:string |
| http://purl.uniprot.org/citations/19124611 | http://purl.uniprot.org/core/pages | "1442-1451"xsd:string |