| http://purl.uniprot.org/citations/19126404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19126404 | http://www.w3.org/2000/01/rdf-schema#comment | "It is well known that oxidative stress plays critical roles in the pathogenesis of atherosclerosis. In this study, we enrolled 1746 type 2 diabetic subjects, determined 4 common genetic variants related to oxidative stress (glutamate-cysteine ligase modifier subunit (GCLM) C-588T, myeloperoxidase G-463A, human paraoxonase 1 Gln192Arg and NAD(P)H oxidase p22phox C242T polymorphisms), and measured carotid intima-media thickness (IMT) as a surrogate marker for atherosclerosis. GCLM C-588T polymorphism was associated with average IMT (AveIMT) (r=0.090, p=0.0008), but the association between the other 3 polymorphisms and AveIMT did not reach the statistical significance. However, AveIMT was significantly greater as the total number of 4 concomitant "pro-oxidant alleles" in each subject was increased (r=0.108, p<0.0001). Furthermore, the number of "pro-oxidant alleles" was a risk factor for a high AveIMT independently of conventional risk factors (p=0.0003). In conclusion, accumulation of oxidative stress-associated alleles was associated with carotid atherosclerosis in type 2 diabetic patients."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.12.154"xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Kashiwagi A."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Sakamoto K."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Yamasaki Y."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Hori M."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Ishibashi F."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Shimizu I."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Kawamori R."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Kaneto H."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Matsuhisa M."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Katakami N."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/author | "Osonoi T."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/pages | "861-865"xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/title | "Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://purl.uniprot.org/core/volume | "379"xsd:string |
| http://purl.uniprot.org/citations/19126404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19126404 |
| http://purl.uniprot.org/citations/19126404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19126404 |
| http://purl.uniprot.org/uniprot/#_A2NU82-mappedCitation-19126404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126404 |
| http://purl.uniprot.org/uniprot/#_A0A7G4RBQ1-mappedCitation-19126404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126404 |
| http://purl.uniprot.org/uniprot/#_A0A7G4RBR1-mappedCitation-19126404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126404 |
| http://purl.uniprot.org/uniprot/#_A0A7G4RBS0-mappedCitation-19126404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126404 |