| http://purl.uniprot.org/citations/19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19126684 | http://www.w3.org/2000/01/rdf-schema#comment | "An increase in glucocorticoid levels and down-regulation of BDNF (brain-derived neurotrophic factor) are supposed to be involved in the pathophysiology of depressive disorders. However, possible crosstalk between glucocorticoid- and BDNF-mediated neuronal functions in the CNS has not been elucidated. Here, we examined whether chronic glucocorticoid exposure influences BDNF-triggered intracellular signaling for glutamate release via a glutamate transporter. We found that chronic exposure to dexamethasone (DEX, a synthetic glucocorticoid) suppressed BDNF-induced glutamate release via weakening the activation of the PLC-gamma (phospholipase C-gamma)/Ca(2+) system in cultured cortical neurons. We demonstrated that the GR (glucocorticoid receptor) interacts with receptor tyrosine kinase for BDNF (TrkB). Following DEX treatment, TrkB-GR interaction was reduced due to the decline in GR expression. Corticosterone, a natural glucocorticoid, also reduced TrkB-GR interaction, BDNF-stimulated PLC-gamma, and BDNF-triggered glutamate release. Interestingly, BDNF-dependent binding of PLC-gamma to TrkB was diminished by DEX. SiRNA transfection to induce a decrease in endogenous GR mimicked the inhibitory action of DEX. Conversely, DEX-inhibited BDNF-activated PLC-gamma signaling for glutamate release was recovered by GR overexpression. We propose that TrkB-GR interaction plays a critical role in the BDNF-stimulated PLC-gamma pathway, which is required for glutamate release, and the decrease in TrkB-GR interaction caused by chronic exposure to glucocorticoids results in the suppression of BDNF-mediated neurotransmitter release via a glutamate transporter."xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0800888106"xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/author | "Adachi N."xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/author | "Izumi A."xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/author | "Kunugi H."xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/author | "Numakawa T."xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/author | "Yagasaki Y."xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/author | "Kumamaru E."xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/pages | "647-652"xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/title | "Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter."xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19126684 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19126684 |
| http://purl.uniprot.org/citations/19126684 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19126684 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K624-mappedCitation-19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126684 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K5X6-mappedCitation-19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126684 |
| http://purl.uniprot.org/uniprot/#_E9PT44-mappedCitation-19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126684 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZVM2-mappedCitation-19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126684 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A088-mappedCitation-19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126684 |
| http://purl.uniprot.org/uniprot/#_A0A0H2UI28-mappedCitation-19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126684 |
| http://purl.uniprot.org/uniprot/#_A6J3I0-mappedCitation-19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126684 |
| http://purl.uniprot.org/uniprot/#_A8IRI3-mappedCitation-19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126684 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZLZ3-mappedCitation-19126684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19126684 |