| http://purl.uniprot.org/citations/19129194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19129194 | http://www.w3.org/2000/01/rdf-schema#comment | "L-selectin is a cell adhesion molecule that tethers leukocytes to the luminal walls of venules during inflammation and enables them to roll under the force of blood flow. Clustering of L-selectin during rolling is thought to promote outside-in signals that lead to integrin activation and chemokine receptor expression, ultimately contributing to leukocyte arrest. Several studies have underscored the importance of the L-selectin cytoplasmic tail in functionally regulating adhesion and signaling. Interestingly, the L-selectin tail comprises only 17 amino acids, and yet it is thought to bind simultaneously to several proteins. For example, constitutive association of calmodulin (CaM) and ezrin/radixin/moesin (ERM) to L-selectin confers resistance to proteolysis and microvillar positioning, respectively. In this report we found that recombinant purified CaM and ERM bound non-competitively to the same tail of L-selectin. Furthermore, molecular modeling supported the possibility that CaM, L-selectin, and moesin could form a heterotrimeric complex. Finally, using fluorescence lifetime imaging microscopy to measure fluorescence resonance energy transfer, it was shown that CaM, L-selectin, and ERM could interact simultaneously in vivo. Moreover, L-selectin clustering promoted CaM/ERM interaction in cis (i.e. derived from neighboring L-selectin tails). These results highlight a novel intracellular event that occurs as a consequence of L-selectin clustering, which could participate in transducing signals that promote the transition from rolling to arrest."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m806983200"xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/author | "Ridley A.J."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/author | "Parsons M."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/author | "Zvelebil M."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/author | "Haskard D.O."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/author | "Ivetic A."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/author | "Ameer-Beg S.M."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/author | "Killock D.J."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/author | "Zarrouk M."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/pages | "8833-8845"xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/title | "In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin."xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19129194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19129194 |
| http://purl.uniprot.org/citations/19129194 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19129194 |
| http://purl.uniprot.org/uniprot/#_A0A0H5AY34-mappedCitation-19129194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129194 |
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| http://purl.uniprot.org/uniprot/#_A0A8V8TKR9-mappedCitation-19129194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129194 |
| http://purl.uniprot.org/uniprot/#_B0YJ88-mappedCitation-19129194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129194 |
| http://purl.uniprot.org/uniprot/#_B7Z437-mappedCitation-19129194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129194 |
| http://purl.uniprot.org/uniprot/#_B7Z4C7-mappedCitation-19129194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129194 |