| http://purl.uniprot.org/citations/19129218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19129218 | http://www.w3.org/2000/01/rdf-schema#comment | "The Torso (Tor) signaling pathway activates tailless (tll) expression by relieving tll repression. None of the repressors identified so far, such as Capicuo, Groucho and Tramtrack69 (Ttk69), bind to the tor response element (tor-RE) or fully elucidate tll repression. In this study, an expanded tll expression pattern was shown in embryos with reduced heat shock factor (hsf) and Trithorax-like (Trl) activities. The GAGA factor, GAF encoded by Trl, bound weakly to the tor-RE, and this binding was enhanced by both Hsf and Ttk69. A similar extent of expansion of tll expression was observed in embryos with simultaneous knockdown of hsf, Trl and ttk69 activities, and in embryos with constitutively active Tor. Hsf is a substrate of mitogen-activated protein kinase and S378 is the major phosphorylation site. Phosphorylation converts Hsf from a repressor to an activator that works with GAF to activate tll expression. In conclusion, the GAF/Hsf/Ttk69 complex binding to the tor-RE remodels local chromatin structure to repress tll expression and the Tor signaling pathway activate tll expression by modulating a dual transcriptional switch."xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkn1036"xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/author | "Chen Y.C."xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/author | "Liaw G.J."xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/author | "Chiang C.S."xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/author | "Lin S.I."xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/author | "Chen Y.K."xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/pages | "1061-1072"xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/title | "The Torso signaling pathway modulates a dual transcriptional switch to regulate tailless expression."xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/19129218 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19129218 |
| http://purl.uniprot.org/citations/19129218 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19129218 |
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| http://purl.uniprot.org/uniprot/Q94517#attribution-3E966887A16C3AC25EE7D62327B2C1F3 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19129218 |
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