| http://purl.uniprot.org/citations/19129405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19129405 | http://www.w3.org/2000/01/rdf-schema#comment | "The extracellular matrix protein Reelin, secreted by Cajal-Retzius cells in the marginal zone of the cortex, controls the radial migration of cortical neurons. Reelin signaling involves the lipoprotein receptors apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR), the adapter protein Disabled1 (Dab1), and phosphatidylinositol-3-kinase (PI3K). Eventually, Reelin signaling acts on the cytoskeleton; however, these effects on cytoskeletal organization have remained elusive. In Reelin-deficient mutant mice, most cortical neurons are unable to migrate to their destinations, suggesting a role for Reelin signaling in the dynamic cytoskeletal reorganization that is required for neurons to migrate. Here, we show that Reelin signaling leads to serine3 phosphorylation of n-cofilin, an actin-depolymerizing protein that promotes the disassembly of F-actin. Phosphorylation at serine3 renders n-cofilin unable to depolymerize F-actin, thereby stabilizing the cytoskeleton. We provide evidence for ApoER2, Dab1, Src family kinases (SFKs), and PI3K to be involved in n-cofilin serine3 phosphorylation. Phosphorylation of n-cofilin takes place in the leading processes of migrating neurons as they approach the Reelin-containing marginal zone. Immunostaining for phospho-cofilin in dissociated reeler neurons is significantly increased after incubation in Reelin-containing medium compared with control medium. In a stripe choice assay, neuronal processes are stable on Reelin-coated stripes but grow on control stripes by forming lamellipodia. These novel findings suggest that Reelin-induced stabilization of neuronal processes anchors them to the marginal zone which appears to be required for the directional migration process."xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2934-08.2009"xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/author | "Zhao S."xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/author | "Chai X."xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/author | "Bock H.H."xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/author | "Frotscher M."xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/author | "Forster E."xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/pages | "288-299"xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/title | "Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3."xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19129405 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19129405 |
| http://purl.uniprot.org/citations/19129405 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19129405 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQI4-mappedCitation-19129405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129405 |
| http://purl.uniprot.org/uniprot/#_E9Q643-mappedCitation-19129405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129405 |
| http://purl.uniprot.org/uniprot/#_A0A571BDC7-mappedCitation-19129405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129405 |
| http://purl.uniprot.org/uniprot/#_A0A571BDQ2-mappedCitation-19129405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129405 |
| http://purl.uniprot.org/uniprot/#_A0A571BE60-mappedCitation-19129405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129405 |
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| http://purl.uniprot.org/uniprot/#_A0A571BEC8-mappedCitation-19129405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129405 |
| http://purl.uniprot.org/uniprot/#_A0A571BEF2-mappedCitation-19129405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129405 |
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| http://purl.uniprot.org/uniprot/#_A0A494B9A7-mappedCitation-19129405 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19129405 |