| http://purl.uniprot.org/citations/19130550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19130550 | http://www.w3.org/2000/01/rdf-schema#comment | "Type I IFN play a very important role in immunity against viral infections. Murine type I IFN belongs to a multigene family including 14 IFN-alpha subtypes but the biological functions of IFN-alpha subtypes in retroviral infections are unknown. We have used the Friend retrovirus model to determine the anti-viral effects of IFN-alpha subtypes in vitro and in vivo. IFN-alpha subtypes alpha1, alpha4, alpha6 or alpha9 suppressed Friend virus (FV) replication in vitro, but differed greatly in their anti-viral efficacy in vivo. Treatment of FV-infected mice with the IFN-alpha subtypes alpha1, alpha4 or alpha9, but not alpha6 led to a significant reduction in viral loads. Decreased splenic viral load after IFN-alpha1 treatment correlated with an expansion of activated FV-specific CD8(+) T cells and NK cells into the spleen, whereas in IFN-alpha4- and -alpha9-treated mice it exclusively correlated with the activation of NK cells. The results demonstrate the distinct anti-retroviral effects of different IFN-alpha subtypes, which may be relevant for new therapeutic approaches."xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200838311"xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/author | "Nair S."xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/author | "James C.M."xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/author | "Dittmer U."xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/author | "Gerlach N."xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/author | "Gibbert K."xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/author | "Zelinskyy G."xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/author | "Alter C."xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/pages | "136-146"xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/title | "Anti-retroviral effects of type I IFN subtypes in vivo."xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/19130550 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19130550 |
| http://purl.uniprot.org/citations/19130550 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19130550 |
| http://purl.uniprot.org/uniprot/P07351#attribution-3A9488AE96E4295EE308C6C5B2DA1597 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19130550 |
| http://purl.uniprot.org/uniprot/P07350#attribution-3A9488AE96E4295EE308C6C5B2DA1597 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19130550 |
| http://purl.uniprot.org/uniprot/P01572#attribution-3A9488AE96E4295EE308C6C5B2DA1597 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19130550 |
| http://purl.uniprot.org/uniprot/P09235#attribution-3A9488AE96E4295EE308C6C5B2DA1597 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19130550 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C3E4-mappedCitation-19130550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19130550 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GV68-mappedCitation-19130550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19130550 |
| http://purl.uniprot.org/uniprot/#_Q149I5-mappedCitation-19130550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19130550 |
| http://purl.uniprot.org/uniprot/#_Q540C2-mappedCitation-19130550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19130550 |