| http://purl.uniprot.org/citations/19136943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19136943 | http://www.w3.org/2000/01/rdf-schema#comment | "Recurrent gene fusions, typically associated with haematological malignancies and rare bone and soft-tissue tumours, have recently been described in common solid tumours. Here we use an integrative analysis of high-throughput long- and short-read transcriptome sequencing of cancer cells to discover novel gene fusions. As a proof of concept, we successfully used integrative transcriptome sequencing to 're-discover' the BCR-ABL1 (ref. 10) gene fusion in a chronic myelogenous leukaemia cell line and the TMPRSS2-ERG gene fusion in a prostate cancer cell line and tissues. Additionally, we nominated, and experimentally validated, novel gene fusions resulting in chimaeric transcripts in cancer cell lines and tumours. Taken together, this study establishes a robust pipeline for the discovery of novel gene chimaeras using high-throughput sequencing, opening up an important class of cancer-related mutations for comprehensive characterization."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07638"xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Han B."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Jing X."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Maher C.A."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Palanisamy N."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Chinnaiyan A.M."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Sam L."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Kalyana-Sundaram S."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Kumar-Sinha C."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/author | "Barrette T."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/pages | "97-101"xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/title | "Transcriptome sequencing to detect gene fusions in cancer."xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://purl.uniprot.org/core/volume | "458"xsd:string |
| http://purl.uniprot.org/citations/19136943 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19136943 |
| http://purl.uniprot.org/citations/19136943 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19136943 |
| http://purl.uniprot.org/uniprot/#_Q8IXL1-mappedCitation-19136943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19136943 |
| http://purl.uniprot.org/uniprot/#_P28324-mappedCitation-19136943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19136943 |
| http://purl.uniprot.org/uniprot/#_Q658X7-mappedCitation-19136943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19136943 |
| http://purl.uniprot.org/uniprot/#_Q96JT2-mappedCitation-19136943 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19136943 |
| http://purl.uniprot.org/uniprot/Q8IXL1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19136943 |