| http://purl.uniprot.org/citations/19136968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19136968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19136968 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear factor-kappaB (NF-kappaB) is a key transcription factor in inflammatory, anti-apoptotic and immune processes. The ubiquitin pathway is crucial in regulating the NF-kappaB pathway. We have found that the LUBAC ligase complex, composed of the two RING finger proteins HOIL-1L and HOIP, conjugates a head-to-tail-linked linear polyubiquitin chain to substrates. Here, we demonstrate that LUBAC activates the canonical NF-kappaB pathway by binding to NEMO (NF-kappaB essential modulator, also called IKKgamma) and conjugates linear polyubiquitin chains onto specific Lys residues in the CC2-LZ domain of NEMO in a Ubc13-independent manner. Moreover, in HOIL-1 knockout mice and cells derived from these mice, NF-kappaB signalling induced by pro-inflammatory cytokines such as TNF-alpha and IL-1beta was suppressed, resulting in enhanced TNF-alpha-induced apoptosis in hepatocytes of HOIL-1 knockout mice. These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1821"xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1821"xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Kato M."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Nakagawa T."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Nakagawa T."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Tokunaga F."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Tokunaga F."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Iwai K."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Iwai K."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Takao T."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Takao T."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Kamei K."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Kamei K."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Sakata S."xsd:string |
| http://purl.uniprot.org/citations/19136968 | http://purl.uniprot.org/core/author | "Sakata S."xsd:string |