| http://purl.uniprot.org/citations/19138172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19138172 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19138172 | http://www.w3.org/2000/01/rdf-schema#comment | "The KChIPs (K(+) channel-interacting proteins) are EF hand-containing proteins required for the traffic of channel-forming Kv4 K(+) subunits to the plasma membrane. KChIP1 is targeted, through N-terminal myristoylation, to intracellular vesicles that appear to be trafficking intermediates from the ER (endoplasmic reticulum) to the Golgi but differ from those underlying conventional ER-Golgi traffic. To define KChIP1 vesicles and the traffic pathway followed by Kv4/KChIP1 traffic, we examined their relationship to potential SNARE (soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptor) proteins mediating the trafficking step. To distinguish Kv4/KChIP1 from conventional constitutive traffic, we compared it to the traffic of the VSVG (vesicular-stomatitis virus G-protein). Expression of KChIP with single or triple EF hand mutations quantitatively inhibited Kv4/KChIP1 traffic to the cell surface but had no effect on VSVG traffic. KChIP1-expressing vesicles co-localized with the SNARE proteins Vti1a and VAMP7 (vesicle-associated membrane protein 7), but not with the components of two other ER-Golgi SNARE complexes. siRNA (small interfering RNA)-mediated knockdown of Vti1a or VAMP7 inhibited Kv4/KChIP1traffic to the plasma membrane in HeLa and Neuro2A cells. Vti1a and VAMP7 siRNA had no effect on VSVG traffic or that of Kv4.2 when stimulated by KChIP2, a KChIP with different intrinsic membrane targeting compared with KChIP1. The present results suggest that a SNARE complex containing VAMP7 and Vti1a defines a novel traffic pathway to the cell surface in both neuronal and non-neuronal cells."xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20081736"xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20081736"xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/author | "Burgoyne R.D."xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/author | "Burgoyne R.D."xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/author | "Flowerdew S.E."xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/author | "Flowerdew S.E."xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/pages | "529-540"xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/pages | "529-540"xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/title | "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels."xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/title | "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels."xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/volume | "418"xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://purl.uniprot.org/core/volume | "418"xsd:string |
| http://purl.uniprot.org/citations/19138172 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19138172 |
| http://purl.uniprot.org/citations/19138172 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19138172 |
| http://purl.uniprot.org/citations/19138172 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19138172 |
| http://purl.uniprot.org/citations/19138172 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19138172 |
| http://purl.uniprot.org/uniprot/O89116 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19138172 |
| http://purl.uniprot.org/uniprot/Q96AJ9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19138172 |