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| http://purl.uniprot.org/citations/19138663 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify whether Topoisomerase I (TopoI) has autonomous circadian rhythms regulated by clock genes, we tested mouse TopoI (mTopoI) promoter oscillation in NIH3T3 cells using a real-time monitoring assay and TopoI mRNA oscillations using real-time RT-PCR. Analysis of the mTopoI promoter region with Matlnspector software revealed two putative E-box (E1 and E2) and one DBP/E4BP4-binding element (D-box). Luciferase assays indicated that mTopoI gene expression was directly regulated by clock genes. The real-time monitoring assay showed that E-box and D-box response elements participate in the regulation of the circadian expression of mTopoI. Furthermore, a gel-shift assay showed that E2 is a direct target of the BMAL1/CLOCK heterodimer and DBP binds to the putative D-site. These results indicate that TopoI is expressed in an autonomous circadian rhythm in NIH3T3 cells."xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.12.186"xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/author | "Ikeda M."xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/author | "Kumagai M."xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/author | "Nakajima Y."xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/author | "Yang F."xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/author | "Ohmiya Y."xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/pages | "22-27"xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/title | "The molecular mechanism regulating the autonomous circadian expression of Topoisomerase I in NIH3T3 cells."xsd:string |
| http://purl.uniprot.org/citations/19138663 | http://purl.uniprot.org/core/volume | "380"xsd:string |
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