| http://purl.uniprot.org/citations/19140872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19140872 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclooxygenase-2 (COX-2) is implicated in pathophysiological processes associated with the initiation or maintenance of host inflammatory responses to infection. Our results demonstrates that Mycobacterium bovis BCG (M. bovis BCG) downregulates tumour necrosis factor-alpha (TNF-alpha)-induced COX-2 gene expression in alveolar epithelial cells by inhibiting the phosphorylations of Raf-1 and p38 kinases. Further, M. bovis BCG-mediated inhibition of COX-2 or p38 mitogen-activated protein kinase could be reversed by Calyculin A, a selective inhibitor of Ser/Thr phosphatases. Moreover, M. bovis BCG inhibited the TNF-alpha-triggered NF-kappaB activation following IkappaB degradation. Taken together, these results suggest that the attenuation of COX-2 expression by vaccine strain, M. bovis BCG, represents a novel strategy to maintain robust host proinflammatory responses to subsequent challenges with virulent tuberculosis bacilli."xsd:string |
| http://purl.uniprot.org/citations/19140872 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-3083.2008.02190.x"xsd:string |
| http://purl.uniprot.org/citations/19140872 | http://purl.uniprot.org/core/author | "Bansal K."xsd:string |
| http://purl.uniprot.org/citations/19140872 | http://purl.uniprot.org/core/author | "Balaji K.N."xsd:string |
| http://purl.uniprot.org/citations/19140872 | http://purl.uniprot.org/core/author | "Narayana Y."xsd:string |
| http://purl.uniprot.org/citations/19140872 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19140872 | http://purl.uniprot.org/core/name | "Scand J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19140872 | http://purl.uniprot.org/core/pages | "11-19"xsd:string |
| http://purl.uniprot.org/citations/19140872 | http://purl.uniprot.org/core/title | "Inhibition of TNF-alpha-induced cyclooxygenase-2 expression by Mycobacterium bovis BCG in human alveolar epithelial A549 cells."xsd:string |
| http://purl.uniprot.org/citations/19140872 | http://purl.uniprot.org/core/volume | "69"xsd:string |
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