| http://purl.uniprot.org/citations/19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19144315 | http://www.w3.org/2000/01/rdf-schema#comment | "It is well established that sustained increases in cyclic AMP (cAMP) such as those triggered by forskolin inhibit T cell activation. We describe here an unexpected phenomenon: in T cells, a transient cAMP increase triggered by the interaction with a dendritic cell strongly potentiates T cell receptor (TCR) signaling. We discovered this effect by examining the molecular basis of the adhesion-dependent sensitization of T cells. T cell adhesion caused extracellular-signal-regulated kinase (ERK) activation, which was necessary for the sensitization process. T cell sensitization could be mimicked in suspended cells by the uncaging of caged cAMP upon ultraviolet illumination. Calcium responses occurring in T cells upon interaction with dendritic cells were strongly inhibited when protein kinase A activation was blocked. Thus, whereas sustained cAMP increases are well known to inhibit TCR signaling, transient cAMP increases occurring physiologically upon formation of an immunological synapse facilitate antigen detection."xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2008.10.020"xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://purl.uniprot.org/core/author | "Randriamampita C."xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://purl.uniprot.org/core/author | "Trautmann A."xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://purl.uniprot.org/core/author | "Boulla G."xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://purl.uniprot.org/core/author | "Conche C."xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19144315 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://purl.uniprot.org/core/pages | "33-43"xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://purl.uniprot.org/core/title | "T cell adhesion primes antigen receptor-induced calcium responses through a transient rise in adenosine 3',5'-cyclic monophosphate."xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/19144315 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19144315 |
| http://purl.uniprot.org/citations/19144315 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19144315 |
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| http://purl.uniprot.org/uniprot/#_A0A1W2P769-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |
| http://purl.uniprot.org/uniprot/#_D3Z446-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |
| http://purl.uniprot.org/uniprot/#_Q63932-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |
| http://purl.uniprot.org/uniprot/#_Q3USU3-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |
| http://purl.uniprot.org/uniprot/#_M0QWN2-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |
| http://purl.uniprot.org/uniprot/#_Q8CB46-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |
| http://purl.uniprot.org/uniprot/#_P31938-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |
| http://purl.uniprot.org/uniprot/#_Q3TMJ8-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |
| http://purl.uniprot.org/uniprot/#_Q3TMW4-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |
| http://purl.uniprot.org/uniprot/#_Q3UK05-mappedCitation-19144315 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19144315 |