| http://purl.uniprot.org/citations/19147100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19147100 | http://www.w3.org/2000/01/rdf-schema#comment | "Environmental stimuli elicit a stress response, which helps to maintain cell survival. In budding yeast Saccharomyces cerevisiae, environmental cues can activate calcineurin, a highly conserved Ca2+-- and calmodulin-dependent protein phosphatase. Calcineurin dephosphorylates the transcription factor Crz1, leading to accumulation of Crz1 in the nuclei and expression of stress responsive genes under the control of a calcineurin-dependent response element (CDRE). Ethanol is the final product of sugar fermentation by yeast, and thus a frequently encountered yeast stressor. However, adaptation of yeast to ethanol stress is poorly understood. In this study, we show that ethanol stimulates calcineurin-dependent nuclear localization of Crz1 and CDRE-dependent gene expression. Moreover, cells in which CRZ1 is deleted exhibit defective adaptation to ethanol stress, while a multicopy plasmid of CRZ1 confers an increased level of adaptive stress tolerance to ethanol. Taken together, the results indicate that ethanol activates the calcineurin/Crz1 pathway and that CRZ1 is crucial for cell survival under ethanol-induced stress."xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jbiosc.2008.09.005"xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/author | "Araki Y."xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/author | "Takagi H."xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/author | "Shimoi H."xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/author | "Akao T."xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/author | "Kitagaki H."xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/name | "J Biosci Bioeng"xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/pages | "1-6"xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/title | "Ethanol stress stimulates the Ca2+-mediated calcineurin/Crz1 pathway in Saccharomyces cerevisiae."xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/19147100 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19147100 |
| http://purl.uniprot.org/citations/19147100 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19147100 |
| http://purl.uniprot.org/uniprot/#_P53968-mappedCitation-19147100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19147100 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BZV6-mappedCitation-19147100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19147100 |
| http://purl.uniprot.org/uniprot/#_A0A6A5Q800-mappedCitation-19147100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19147100 |
| http://purl.uniprot.org/uniprot/#_P23287-mappedCitation-19147100 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19147100 |
| http://purl.uniprot.org/uniprot/A0A8H4BZV6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19147100 |
| http://purl.uniprot.org/uniprot/P23287 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19147100 |
| http://purl.uniprot.org/uniprot/A0A6A5Q800 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19147100 |
| http://purl.uniprot.org/uniprot/P53968 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19147100 |