| http://purl.uniprot.org/citations/19147495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19147495 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19147495 | http://www.w3.org/2000/01/rdf-schema#comment | "The SLC6 family of structurally related, Na(+)-dependent transporter proteins is responsible for presynaptic reuptake of the majority of neurotransmitters. Within this family are a number of orphan transporters, including NTT4/XT1 (SLC6A17), a protein first identified over 15 years ago. NTT4/XT1 is expressed exclusively in the nervous system and specifically on synaptic vesicles in glutamatergic and some GABAergic neurons. Despite extensive efforts by a number of groups, no substrate has been reported for NTT4/XT1. Here we use a combination of molecular manipulations to increase expression of the NTT4/XT1 protein at the plasma membrane and to directly demonstrate that it catalyzes neutral amino acid transport. The substrate profile of the NTT4/XT1-dependent activity is similar to that of the closely related B(0)AT2/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine. The transport activity is Na(+)-dependent and Cl(-)-independent and is inhibited by low pH as is SLC6A15, suggesting redundant roles for these proteins. This characterization of NTT4/XT1 offers important insights into neurotransmitter metabolism as well as the mechanistic differences among the structurally related, but functionally divergent, SLC6 proteins."xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m806407200"xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m806407200"xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/author | "Reimer R.J."xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/author | "Reimer R.J."xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/author | "Zaia K.A."xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/author | "Zaia K.A."xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/pages | "8439-8448"xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/pages | "8439-8448"xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/title | "Synaptic vesicle protein NTT4/XT1 (SLC6A17) catalyzes Na+-coupled neutral amino acid transport."xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/title | "Synaptic vesicle protein NTT4/XT1 (SLC6A17) catalyzes Na+-coupled neutral amino acid transport."xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19147495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19147495 |
| http://purl.uniprot.org/citations/19147495 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19147495 |
| http://purl.uniprot.org/citations/19147495 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19147495 |
| http://purl.uniprot.org/citations/19147495 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19147495 |
| http://purl.uniprot.org/uniprot/P31662 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19147495 |
| http://purl.uniprot.org/uniprot/P31662#attribution-5279A5B7F602C933565DC3D8DF7B7FDB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19147495 |