| http://purl.uniprot.org/citations/19147787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19147787 | http://www.w3.org/2000/01/rdf-schema#comment | "B-cell lymphoma is the most common immune system malignancy. TCL1 transgenic mice (TCL1-tg), in which TCL1 is ectopically expressed in mature lymphocytes, develop multiple B- and T-cell leukemia and lymphoma subtypes, supporting an oncogenic role for TCL1 that probably involves AKT and MAPK-ERK signaling pathway augmentation. Additional, largely unknown genetic and epigenetic alterations cooperate with TCL1 during lymphoma progression. We examined DNA methylation patterns in TCL1-tg B-cell tumors to discover tumor-associated epigenetic changes, and identified hypermethylation of sprouty2 (Spry2). Sprouty proteins are context-dependent negative or positive regulators of MAPK-ERK pathway signaling, but their role(s) in B-cell physiology or pathology are unknown. Here we show that repression of Spry2 expression in TCL1-tg mouse and human B-cell lymphomas and cell lines is associated with dense DNA hypermethylation and was reversed by inhibition of DNA methylation. Spry2 expression was induced in normal splenic B cells by CD40/B-cell receptor costimulation and regulated a negative feedback loop that repressed MAPK-ERK signaling and decreased B-cell viability. Conversely, loss of Spry2 function hyperactivated MAPK-ERK signaling and caused increased B-cell proliferation. Combined, these results implicate epigenetic silencing of Spry2 expression in B lymphoma progression and suggest it as a companion lesion to ectopic TCL1 expression in enhancing MAPK-ERK pathway signaling."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2008-05-156943"xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Hong J.S."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Bar-Sagi D."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Frank M.J."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Martin G.R."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Shen R.R."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Knosp W.M."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Teitell M.A."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Dawson D.W."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Bensinger S.J."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Allen E.L."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/author | "Balatoni C.E."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/pages | "2478-2487"xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/title | "Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas."xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://purl.uniprot.org/core/volume | "113"xsd:string |
| http://purl.uniprot.org/citations/19147787 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19147787 |
| http://purl.uniprot.org/citations/19147787 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19147787 |
| http://purl.uniprot.org/uniprot/#_B2RS85-mappedCitation-19147787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19147787 |
| http://purl.uniprot.org/uniprot/#_Q7Z783-mappedCitation-19147787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19147787 |
| http://purl.uniprot.org/uniprot/#_O43597-mappedCitation-19147787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19147787 |