| http://purl.uniprot.org/citations/19151157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19151157 | http://www.w3.org/2000/01/rdf-schema#comment | "Clathrin is a coat protein involved in vesicle budding from several membrane-bound compartments within the cell. Here we present an analysis of a temperature-sensitive (ts) mutant of clathrin heavy chain (CHC) in a multicellular animal. As expected Caenorhabditis elegans chc-1(b1025ts) mutant animals are defective in receptor-mediated endocytosis and arrest development soon after being shifted to the restrictive temperature. Steady-state clathrin levels in these mutants are reduced by more than 95% at all temperatures. Hub interactions and membrane associations are lost at the restrictive temperature. chc-1(b1025ts) animals become paralyzed within minutes of exposure to the restrictive temperature because of a defect in the nervous system. Surprisingly synaptic vesicle number is not reduced in chc-1(b1025ts) animals. Consistent with the normal number of vesicles, postsynaptic miniature currents occur at normal frequencies. Taken together, these results indicate that a high level of CHC activity is required for receptor-mediated endocytosis in nonneuronal cells but is largely dispensable for maintenance of synaptic vesicle pools."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0809541106"xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/author | "Sato M."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/author | "Siddiqui A."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/author | "Watanabe S."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/author | "Weimer R.M."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/author | "Grant B.D."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/author | "Jorgensen E.M."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/author | "Ernstrom G.G."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/pages | "1139-1144"xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/title | "Differential requirements for clathrin in receptor-mediated endocytosis and maintenance of synaptic vesicle pools."xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19151157 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19151157 |
| http://purl.uniprot.org/citations/19151157 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19151157 |
| http://purl.uniprot.org/uniprot/P34574#attribution-7DECF5ABC7265D2BEACDAB4A9846C474 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19151157 |
| http://purl.uniprot.org/uniprot/#_P34574-mappedCitation-19151157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19151157 |
| http://purl.uniprot.org/uniprot/#_G4S3B4-mappedCitation-19151157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19151157 |
| http://purl.uniprot.org/uniprot/#_P90961-mappedCitation-19151157 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19151157 |
| http://purl.uniprot.org/uniprot/P34574 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19151157 |
| http://purl.uniprot.org/uniprot/P90961 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19151157 |