| http://purl.uniprot.org/citations/19152396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19152396 | http://www.w3.org/2000/01/rdf-schema#comment | "The development of HTLV-1 associated clinical manifestations, such as TSP/HAM and ATLL, occur in 2-4% of the infected population and it is still unclear why this infection remains asymptomatic in most infected carriers. Recently, it has been demonstrated that HTLV uses the Glucose transporter type 1 (GLUT1) to infect T-CD4(+) lymphocytes and that single nucleotide polymorphisms (SNP) in the GLUT1 gene are associated with diabetic nephropathy in patients with diabetes mellitus in different populations. These polymorphisms could contribute to a higher GLUT1 protein expression on cellular membrane, facilitating the entry of HTLV and its transmission cell by cell. This could result in a higher provirus load and consequently in the development of TSP/HAM. To evaluate the role of GLUT1 gene polymorphisms in the development of TSP/HAM in HTLV-1 infected individuals, the g.22999G > T, g.15339T > C and c.-2841A > T sites were analyzed by PCR/RFLP or sequencing in 244 infected individuals and 102 normal controls. The proviral load of the HTLV-1 infected patients was also analyzed using Real Time Quantitative PCR. Genotypic and allelic frequencies of the three sites did not differ significantly between controls and HTLV-1 infected individuals. There was no difference in genotypic and allelic distributions among patients as to the presence or absence of HTLV-1 associated clinic manifestations. As regards the quantification of the provirus load, we observed a significant reduction in the asymptomatic individuals compared with the oligosymptomatic and TSP/HAM individuals. These results suggest that g.22999G > T, g.15339T > C, and c.-2841A > T SNP do not contribute to HTLV-1 infection nor to the genetic susceptibility of TSP/HAM in Brazilian HTLV-1 infected individuals."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.org/dc/terms/identifier | "doi:10.1002/jmv.21421"xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Galvao-Castro B."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Azevedo R."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Covas D.T."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Muricy G."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Costa G.C."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Alcantara L.C."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Takayanagui O.M."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Gadelha S.R."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Kashima S.H."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/author | "Olavarria V.N."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/name | "J Med Virol"xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/pages | "552-557"xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/title | "Polymorphisms at GLUT1 gene are not associated with the development of TSP/HAM in Brazilian HTLV-1 infected individuals and the discovery of a new polymorphism at GLUT1 gene."xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://purl.uniprot.org/core/volume | "81"xsd:string |
| http://purl.uniprot.org/citations/19152396 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19152396 |
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| http://purl.uniprot.org/uniprot/#_B4DKW1-mappedCitation-19152396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19152396 |