| http://purl.uniprot.org/citations/19153666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19153666 | http://www.w3.org/2000/01/rdf-schema#comment | "The acrosome reaction has long been thought to be induced by the zona pellucida. Here we report the identification and function of a novel human sperm glycosylphosphatidylinositol (GPI)-anchored membrane protein, NYD-SP8. The release of the protein during sperm-egg interaction and its binding to the cumulus, the first layer of egg investment, elicits cross-talk between the gametes and produces calcium dependant release of progesterone, which lead to the acrosome reaction. An in vivo mouse model of NYD-SP8 immunization is also established showing a reduced fertility rate. Thus, contrary to accepted dogma, our study demonstrates for the first time that, prior to reaching the zona pellucida, sperm may release a surface protein that acts on the cumulus cells leading to the acrosome reaction, which may be important for determining the outcome of fertilization."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00018-009-8482-2"xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Cai Y."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Liu H."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Li K."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Bi Y."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Ma M."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Xu W."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Zhou Z."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Zhou C."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Zhu H."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Sha J."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Zhao C."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Shi Q."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Yin L."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Ni Y."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Chen W.Y."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Chan H.C."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Fok K.L."xsd:string |
| http://purl.uniprot.org/citations/19153666 | http://purl.uniprot.org/core/author | "Chung C.M."xsd:string |