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http://purl.uniprot.org/citations/19154418http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19154418http://www.w3.org/2000/01/rdf-schema#comment"Chicken ovalbumin upstream promoter transcription factors (COUP-TF) are orphan members of the nuclear receptor superfamily and consist of COUP-TFI and COUP-TFII. COUP-TFI was reported to be overexpressed in human breast cancer and to promote estrogen-independent transcriptional activity of estrogen receptor alpha. COUP-TFII, however, has not been examined in the breast. Therefore, we carried out immunohistochemical analysis of COUP-TFII in human breast cancer in order to clarify its biological and clinical significance. We immunolocalized COUP-TFII in 119 human breast cancers and correlated the findings with various clinicopathological parameters. Fifty-nine percent of the cases were immunohistochemically positive for COUP-TFII. COUP-TFII positivity was correlated with poor clinical outcome, and a statistically significant correlation was detected between COUP-TFII and the following clinicopathological parameters: clinical stage, lymph node status, histological grade, and estrogen receptor alpha status. In addition, short interfering RNA-mediated knockdown of COUP-TFII in the breast carcinoma cell line MCF-7 decreased the level of vascular endothelial growth factor-C mRNA expression, which is a known inducer of lymphangiogenesis and lymph node metastasis. These results suggest that COUP-TFII is involved in the development of advanced human breast cancer."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.org/dc/terms/identifier"doi:10.1111/j.1349-7006.2008.01078.x"xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/author"Ishida T."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/author"Miki Y."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/author"Suzuki T."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/author"Shibata H."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/author"Sasano H."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/author"Nagasaki S."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/author"Ohuchi N."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/author"Akahira J."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/name"Cancer Sci"xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/pages"639-645"xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/title"Chicken ovalbumin upstream promoter transcription factor II in human breast carcinoma: possible regulator of lymphangiogenesis via vascular endothelial growth factor-C expression."xsd:string
http://purl.uniprot.org/citations/19154418http://purl.uniprot.org/core/volume"100"xsd:string
http://purl.uniprot.org/citations/19154418http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19154418
http://purl.uniprot.org/citations/19154418http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19154418
http://purl.uniprot.org/uniprot/#_F1D8R0-mappedCitation-19154418http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19154418
http://purl.uniprot.org/uniprot/#_P24468-mappedCitation-19154418http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19154418
http://purl.uniprot.org/uniprot/F1D8R0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19154418
http://purl.uniprot.org/uniprot/P24468http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/19154418