| http://purl.uniprot.org/citations/19155308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19155308 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclin-dependent kinase 6 (CDK6) promotes cell cycle progression and is overexpressed in human lymphoid malignancies. To determine the role of CDK6 in development and tumorigenesis, we generated and analyzed knockout mice. Cdk6-deficient mice show pronounced thymic atrophy due to reduced proliferative fractions and concomitant transitional blocks in the double-negative stages. Using the OP9-DL1 system to deliver temporally controlled Notch receptor-dependent signaling, we show that CDK6 is required for Notch-dependent survival, proliferation, and differentiation. Furthermore, CDK6-deficient mice were resistant to lymphomagenesis induced by active Akt, a downstream target of Notch signaling. These results show a critical requirement for CDK6 in Notch/Akt-dependent T-cell development and tumorigenesis and strongly support CDK6 as a specific therapeutic target in human lymphoid malignancies."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-08-2473"xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Mao C."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Tsichlis P.N."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Chang R."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Hu G.F."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Gounari F."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Deshpande A."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Mao D."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Dose M."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Hinds E.A."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Hinds P.W."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Hu M.G."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/author | "Enos M."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/pages | "810-818"xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/title | "A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/19155308 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19155308 |
| http://purl.uniprot.org/citations/19155308 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19155308 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGA8-mappedCitation-19155308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155308 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGH2-mappedCitation-19155308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155308 |