| http://purl.uniprot.org/citations/19155466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19155466 | http://www.w3.org/2000/01/rdf-schema#comment | "Histamine (HA) is a biogenic amine with multiple activities in the immune system. In this study we demonstrate that histamine-free histidine decarboxylase-deficient (HDC(-/-)) mice present a numerical and functional deficit in invariant NK T (iNKT) cells as evidenced by a drastic decrease of IL-4 and IFN-gamma production. This deficiency was established both by measuring cytokine levels in the serum and intracellularly among gated iNKT cells. It resulted from the lack of HA, because a single injection of this amine into HDC(-/-) mice sufficed to restore normal IL-4 and IFN-gamma production. HA-induced functional recovery was mediated mainly through the H4 histamine receptor (H4R), as assessed by its abrogation after a single injection of a selective H4R antagonist and the demonstration of a similar iNKT cell deficit in H4R(-/-) mice. Our findings identify a novel function of HA through its H4R and suggest that it might become instrumental in modulating iNKT cell functions."xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.182.3.1233"xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/author | "Schneider E."xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/author | "Michel M.L."xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/author | "Thurmond R.L."xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/author | "Ohtsu H."xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/author | "Dy M."xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/author | "Leite-de-Moraes M.C."xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/author | "Diem S."xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/pages | "1233-1236"xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/title | "Cutting edge: histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells."xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19155466 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19155466 |
| http://purl.uniprot.org/citations/19155466 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19155466 |
| http://purl.uniprot.org/uniprot/#_B2ZGH2-mappedCitation-19155466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155466 |
| http://purl.uniprot.org/uniprot/#_B2ZGH3-mappedCitation-19155466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155466 |
| http://purl.uniprot.org/uniprot/#_Q7TMW5-mappedCitation-19155466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155466 |
| http://purl.uniprot.org/uniprot/#_Q2M2N7-mappedCitation-19155466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155466 |
| http://purl.uniprot.org/uniprot/#_P23738-mappedCitation-19155466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155466 |
| http://purl.uniprot.org/uniprot/#_Q91ZY2-mappedCitation-19155466 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155466 |
| http://purl.uniprot.org/uniprot/Q2M2N7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19155466 |
| http://purl.uniprot.org/uniprot/B2ZGH3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19155466 |