| http://purl.uniprot.org/citations/19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19155500 | http://www.w3.org/2000/01/rdf-schema#comment | "Conventional CD8(+) T cell responses against intracellular infectious agents are initiated upon recognition of pathogen-derived peptides presented at the cell surface of infected cells in the context of MHC class I molecules. Among the major MHC class I loci, HLA-B is the swiftest evolving and the most polymorphic locus. Additionally, responses restricted by HLA-B molecules tend to be dominant, and most associations with susceptibility or protection against infectious diseases have been assigned to HLA-B alleles. To assess whether the differences in responses mediated via two major HLA class I loci, HLA-B and HLA-A, may already begin at the Ag presentation level, we have analyzed the diversity and binding affinity of their peptide repertoire by making use of curated pathogen-derived epitope data retrieved from the Immune Epitope Database and Analysis Resource, as well as in silico predicted epitopes. In contrast to our expectations, HLA-B alleles were found to have a less diverse peptide repertoire, which points toward a more restricted binding motif, and the respective average peptide binding affinity was shown to be lower than that of HLA-A-restricted epitopes. This unexpected observation gives rise to new hypotheses concerning the mechanisms underlying immunodominance of CD8(+) T cell responses."xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.182.3.1526"xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://purl.uniprot.org/core/author | "Rao X."xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://purl.uniprot.org/core/author | "Kesmir C."xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://purl.uniprot.org/core/author | "van Baarle D."xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://purl.uniprot.org/core/author | "Costa A.I."xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19155500 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://purl.uniprot.org/core/pages | "1526-1532"xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://purl.uniprot.org/core/title | "A comparative study of HLA binding affinity and ligand diversity: implications for generating immunodominant CD8+ T cell responses."xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://purl.uniprot.org/core/volume | "182"xsd:string |
| http://purl.uniprot.org/citations/19155500 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19155500 |
| http://purl.uniprot.org/citations/19155500 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N5-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |
| http://purl.uniprot.org/uniprot/#_A0A068B112-mappedCitation-19155500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19155500 |