| http://purl.uniprot.org/citations/19158675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19158675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19158675 | http://www.w3.org/2000/01/rdf-schema#comment | "The innate immune system senses nucleic acids by germline-encoded pattern recognition receptors. RNA is sensed by Toll-like receptor members TLR3, TLR7 and TLR8, or by the RNA helicases RIG-I (also known as DDX58) and MDA-5 (IFIH1). Little is known about sensors for cytoplasmic DNA that trigger antiviral and/or inflammatory responses. The best characterized of these responses involves activation of the TANK-binding kinase (TBK1)-interferon regulatory factor 3 (IRF3) signalling axis to trigger transcriptional induction of type I interferon genes. A second, less well-defined pathway leads to the activation of an 'inflammasome' that, via caspase-1, controls the catalytic cleavage of the pro-forms of the cytokines IL1beta and IL18 (refs 6, 7). Using mouse and human cells, here we identify the PYHIN (pyrin and HIN domain-containing protein) family member absent in melanoma 2 (AIM2) as a receptor for cytosolic DNA, which regulates caspase-1. The HIN200 domain of AIM2 binds to DNA, whereas the pyrin domain (but not that of the other PYHIN family members) associates with the adaptor molecule ASC (apoptosis-associated speck-like protein containing a caspase activation and recruitment domain) to activate both NF-kappaB and caspase-1. Knockdown of Aim2 abrogates caspase-1 activation in response to cytoplasmic double-stranded DNA and the double-stranded DNA vaccinia virus. Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07725"xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07725"xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Horvath G."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Horvath G."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Ablasser A."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Ablasser A."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Bauernfeind F."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Bauernfeind F."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Caffrey D.R."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Caffrey D.R."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Charrel-Dennis M."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Charrel-Dennis M."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Hornung V."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Hornung V."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Latz E."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/author | "Latz E."xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/19158675 | http://purl.uniprot.org/core/name | "Nature"xsd:string |