| http://purl.uniprot.org/citations/19158679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19158679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19158679 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytoplasmic DNA triggers activation of the innate immune system. Although 'downstream' signaling components have been characterized, the DNA-sensing components remain elusive. Here we present a systematic proteomics screen for proteins that associate with DNA, 'crossed' to a screen for transcripts induced by interferon-beta, which identified AIM2 as a candidate cytoplasmic DNA sensor. AIM2 showed specificity for double-stranded DNA. It also recruited the inflammasome adaptor ASC and localized to ASC 'speckles'. A decrease in AIM2 expression produced by RNA-mediated interference impaired DNA-induced maturation of interleukin 1beta in THP-1 human monocytic cells, which indicated that endogenous AIM2 is required for DNA recognition. Reconstitution of unresponsive HEK293 cells with AIM2, ASC, caspase-1 and interleukin 1beta showed that AIM2 was sufficient for inflammasome activation. Our data suggest that AIM2 is a cytoplasmic DNA sensor for the inflammasome."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1702"xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1702"xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Bennett K.L."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Bennett K.L."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Colinge J."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Colinge J."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Planyavsky M."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Planyavsky M."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Superti-Furga G."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Baumann C."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Baumann C."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Bilban M."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Bilban M."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Bluml S."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Bluml S."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Burckstummer T."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Burckstummer T."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Dixit E."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Dixit E."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Durnberger G."xsd:string |
| http://purl.uniprot.org/citations/19158679 | http://purl.uniprot.org/core/author | "Durnberger G."xsd:string |