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http://purl.uniprot.org/citations/19160960http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19160960http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To explore the expression of PD-1-PD-L pathway of mice immunized with soluble egg antigen (SEA) or soluble male worm antigen (SMWA) of Schistosoma japonicum.

Methods

Eighteen BALB/c mice were randomly divided into three groups named as control group (A), SEA immunized group (B) and SMWA immunized group (C). Mice in groups B and C were subcutaneously immunized weekly with SEA (50 microg) and SMWA (50 microg) of S. japonicum respectively. After 4 times immunization, the expression of programmed death-1 (PD-1), programmed death-ligand1 (PD-L1) and PD-L2 in splenic cells was measured with flow cytometer. The expression of IL-4 and IFN-gamma in cultural suspension of splenic cells was detected by sandwich-ELISA after stimulation with ConA.

Results

The expression ratio of PD-1, PD-L1 and PD-L2 was extremely low in the control group, but increased after the immunization with SEA and SMWA. The expression ratio of PD-1 was (8.24 +/-1.31)% in SEA immunized mice, higher than the mice immunized by SMWA [(6.08 +/-1.28)%]. PD-L2 was much more elevated in SEA immunized mice [(5.26 +/-1.73)%] while PD-L1 more significantly increased with SMWA immunization [(10.82 +/-2.33)%]. In addition, the up-expression of PD-L1 was associated with the level of IFN-gamma and the expression of PD-L2 was associated with IL-4 secretion.

Conclusion

The expression of PD-1-PDL was up-regulated in BALB/c mice immunized by SEA or SMWA of S. japonicum."xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/author"Li Y.L."xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/author"Wang Q.H."xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/author"Cheng Y.L."xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/author"Liu W.Q."xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/author"Jiang Z.W."xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/author"Mo H.M."xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/name"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi"xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/pages"170-173"xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/title"[Up-expression of PD-1-PD-L induced by immunization with SEA and SMWA of Schistosoma japonicum in mice]."xsd:string
http://purl.uniprot.org/citations/19160960http://purl.uniprot.org/core/volume"26"xsd:string
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