| http://purl.uniprot.org/citations/19164550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19164550 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19164550 | http://www.w3.org/2000/01/rdf-schema#comment | "gC1qR is one of the C1q receptors implicated in the regulation of innate and adaptive immunity. We found that gC1qR inhibits RIG-I and MDA5-dependent antiviral signaling. Double stranded RNA and virus trigger the translocation of gC1qR to the mitochondrial outer membrane leading to the interaction of gC1qR with the RIG-I and MDA5 adaptor, VISA/MAVS/IPS-1/Cardif. The interaction of gC1qR with VISA/MAVS/IPS-1/Cardif at mitochondria results in the disruption of RIG-I and MDA5 signaling and the promotion of virus replication. Knockdown of endogenous gC1qR enhances RIG-I-dependent antiviral signaling, and augments the inhibition of virus proliferation. Therefore, gC1qR is a physiological inhibitor of the RIG-I and MDA5-mediated antiviral signaling pathway. These data uncover a new viral mechanism used to negatively control antiviral signaling in host cells."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0811029106"xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0811029106"xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Gu J."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Liu F."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Xu L."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Ren H."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Ren H."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Xiao N."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/author | "Xiao N."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/pages | "1530-1535"xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/pages | "1530-1535"xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/title | "Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/title | "Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria."xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/19164550 | http://purl.uniprot.org/core/volume | "106"xsd:string |