| http://purl.uniprot.org/citations/19165146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19165146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19165146 | http://www.w3.org/2000/01/rdf-schema#comment | "In metazoans, nuclear export of bulk mRNA is mediated by Tap-p15, a conserved heterodimeric export receptor that cooperates with adaptor RNA-binding proteins. In this article, we show that Thoc5, a subunit of the mammalian TREX complex, binds to a distinct surface on the middle (Ntf2-like) domain of Tap. Notably, adaptor protein Aly and Thoc5 can simultaneously bind to non-overlapping binding sites on Tap-p15. In vivo, Thoc5 was not required for bulk mRNA export. However, nuclear export of HSP70 mRNA depends on both Thoc5 and Aly. Consistent with a function as a specific export adaptor, Thoc5 exhibits in vitro RNA-binding activity and is associated with HSP70 mRNPs in vivo as a component of the stable THO complex. Thus, through the combinatorial use of an adaptor (e.g., Aly) and co-adapter (e.g., Thoc5), Tap-p15 could function as an export receptor for different classes of mRNAs."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.5"xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2009.5"xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/author | "Inoue H."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/author | "Inoue H."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/author | "Yoneda Y."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/author | "Yoneda Y."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/author | "Hurt E."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/author | "Hurt E."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/author | "Katahira J."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/author | "Katahira J."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/pages | "556-567"xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/pages | "556-567"xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/title | "Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/title | "Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA."xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://purl.uniprot.org/core/volume | "28"xsd:string |
| http://purl.uniprot.org/citations/19165146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19165146 |
| http://purl.uniprot.org/citations/19165146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19165146 |