| http://purl.uniprot.org/citations/19165826 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19165826 | http://www.w3.org/2000/01/rdf-schema#comment | "To address the requirement for TGFbeta signaling in the formation and maintenance of the vascular matrix, we employed lineage-specific mutation of the type II TGFbeta receptor gene (Tgfbr2) in vascular smooth muscle precursors in mice. In both neural crest- and mesoderm-derived smooth muscle, absence of TGFbeta receptor function resulted in a poorly organized vascular elastic matrix in late-stage embryos which was prone to dilation and aneurysm. This defect represents a failure to initiate formation of the elastic matrix, rather than a failure to maintain a preexisting matrix. In mutant tissue, lysyl oxidase expression was substantially reduced, which may contribute to the observed pathology."xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvg.20466"xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/author | "Thomas S."xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/author | "Kaartinen V."xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/author | "Sucov H.M."xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/author | "Choudhary B."xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/name | "Genesis"xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/pages | "115-121"xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/title | "Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm."xsd:string |
| http://purl.uniprot.org/citations/19165826 | http://purl.uniprot.org/core/volume | "47"xsd:string |
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