http://purl.uniprot.org/citations/19166343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/19166343 | http://www.w3.org/2000/01/rdf-schema#comment | "The LEM (LAP2beta, Emerin, and MAN1) proteins are essential for nuclear membrane targeting to chromatin via an association with barrier-to-autointegration factor (BAF). Herein, we focused on the mitotic phosphorylation of MAN1 and its biological role. MAN1 was phosphorylated in a cell cycle-dependent manner in the Xenopus egg cell-free system, and the mitotic phosphorylation at the N-terminal region of MAN1 suppressed the binding of MAN1 to BAF. Titansphere column chromatography followed by MS/MS sequencing identified at least three M-phase-specific phosphorylation sites, Thr-209, Ser-351, and Ser-402, and one cell cycle-independent phosphorylation site, Ser-463. An in vitro BAF binding assay involving mutants S402A and S402E suggested that the phosphorylation of Ser-402 was important for regulation of the binding of MAN1 to BAF."xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi802060v"xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/author | "Ishii K."xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/author | "Takeyasu K."xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/author | "Hirano Y."xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/author | "Horigome T."xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/author | "Kumeta M."xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/author | "Iwase Y."xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/pages | "1636-1643"xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/title | "Cell cycle-dependent phosphorylation of MAN1."xsd:string |
http://purl.uniprot.org/citations/19166343 | http://purl.uniprot.org/core/volume | "48"xsd:string |
http://purl.uniprot.org/citations/19166343 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19166343 |
http://purl.uniprot.org/citations/19166343 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19166343 |
http://purl.uniprot.org/uniprot/#_Q9Y2U8-mappedCitation-19166343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19166343 |
http://purl.uniprot.org/uniprot/Q9Y2U8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19166343 |